After an MI or stroke, risk of another CV event is ~ 1 in 3. With symptomatic PAD, risk of a CV event is ~ 1 in 4 After an MI or stroke, risk of another CV event is ~ 1 in 3. With symptomatic PAD, risk of a CV event is ~ 1 in 4

*CV event defined as CV death, MI, stroke, and CV hospitalization. Based on a 4-year follow-up. Endpoints were not adjudicated. Stroke defined as documented cerebrovascular disease consisting of a neurologist report or hospital report with the diagnosis of ischemic stroke or transient ischemic attack. Source: REACH Registry is a multinational database with N = 45,227 patients of which 21,890 patients had prior ischemic event. 73% were on statin therapy at baseline, enrolled between 2003 and 2004 and followed up until 2008.1

CV event defined as major coronary event, stroke of any type, and coronary or non-coronary revascularization. Based on a mean 5-year follow-up. Source: The Heart Protection Study (HPS) randomized clinical trial with N = 20,536 patients, of which 6,748 patients had PAD and were randomly allocated to 40 mg simvastatin daily, conducted in the UK, enrolled between July 1994 and May 1997.2

MI = myocardial infarction. PAD = peripheral artery disease; defined as a history of intermittent claudication (with or without supporting vascular investigations) or previous peripheral arterial revascularization procedure, amputation, or aneurysm repair.