After an


risk of another CV event is

1,*~1 in 32,*

With symptomatic


risk of a CV event is

2,†~1 in 43,†

Updated 2018 AHA/ACC guidelines on the management of blood cholesterol recommend 70 mg/dL as the new threshold to trigger action in very high-risk patients4

CV Risk Remains: Expert Perspectives

Gain expert insights on the risk of another MI or stroke in your CVD patients with Dr. Harold Bays and Dr. Seth Baum.

*CV event defined as CV death, MI, stroke, and CV hospitalization. Based on a 4-year follow-up. Endpoints were not adjudicated. Stroke defined as documented cerebrovascular disease consisting of a neurologist report or hospital report with the diagnosis of ischemic stroke or transient ischemic attack. Source: REACH Registry is a multinational database with N = 45,227 patients of which 21,890 patients had prior ischemic event. 73% were on statin therapy at baseline, enrolled between 2003 and 2004 and followed up until 2008.1

CV event defined as major coronary event, stroke of any type, and coronary or non-coronary revascularization. Based on a mean 5-year follow-up. Source: The Heart Protection Study (HPS) randomized clinical trial with N = 20,536 patients, of which 6,748 patients had PAD and were randomly allocated to 40 mg simvastatin daily, conducted in the UK, enrolled between July 1994 and May 1997.2

Very high-risk includes a history of multiple major ASCVD events or 1 major ASCVD event and multiple high-risk conditions. Symptomatic peripheral arterial disease (history of claudication with ABI <0.85, or previous revascularization or amputation). When on clinically judged maximally tolerated lipid-lowering therapy (statins + ezetimibe).

ABI = ankle brachial index; AHA/ACC = American Heart Association/American College of Cardiology; ASCVD = atherosclerotic cardiovascular disease; CV = cardiovascular; MI = myocardial infarction; PAD = peripheral artery disease.